Hiroaki Iwata Selected Research

Epitopes

7/2020	Epitope spreading possibly from BP230 to the NC16A domain of BP180 preceding disease progression in bullous pemphigoid.
1/2019	Immune Reaction to Type XVII Collagen Induces Intramolecular and Intermolecular Epitope Spreading in Experimental Bullous Pemphigoid Models.
11/2016	Autoantibody Profile Differentiates between Inflammatory and Noninflammatory Bullous Pemphigoid.
1/2016	Epitope-Dependent Pathogenicity of Antibodies Targeting a Major Bullous Pemphigoid Autoantigen Collagen XVII/BP180.
6/2015	Autoantibodies to Multiple Epitopes on the Non-Collagenous-1 Domain of Type VII Collagen Induce Blisters.
5/2015	Prevalence of pemphigus and pemphigoid autoantibodies in the general population.

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Hiroaki Iwata Research Topics

Disease

30	Bullous Pemphigoid (Pemphigoid) 03/2022 - 04/2009
12	Epidermolysis Bullosa Acquisita (Acquired Epidermolysis Bullosa) 01/2022 - 09/2012
9	Blister (Bulla) 12/2021 - 06/2013
7	Inflammation (Inflammations) 01/2022 - 04/2009
6	Autoimmune Diseases (Autoimmune Disease) 11/2020 - 09/2012
5	Pemphigus (Pemphigus Vulgaris) 12/2021 - 05/2015
3	Erythema 12/2017 - 06/2013
3	Skin Diseases (Skin Disease) 01/2017 - 01/2013
2	Disease Progression 03/2022 - 07/2020
2	Epidermolysis Bullosa Dystrophica (Dystrophic Epidermolysis Bullosa) 01/2022 - 01/2019
2	Psoriasis (Pustulosis Palmaris et Plantaris) 09/2021 - 01/2015
2	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 11/2019 - 12/2018
2	Neoplasms (Cancer) 11/2019 - 02/2015
2	Melanoma (Melanoma, Malignant) 12/2017 - 04/2012
2	Linear IgA Bullous Dermatosis 12/2017 - 10/2017
2	Vesiculobullous Skin Diseases (Subcorneal Pustular Dermatosis) 04/2015 - 09/2013
1	Wounds and Injuries (Trauma) 01/2022
1	Hidradenitis Suppurativa 01/2022
1	Japanese Encephalitis 01/2022
1	Epidermolysis Bullosa 01/2022
1	Infections 01/2022
1	Animal Disease Models 12/2021
1	Communicable Diseases (Infectious Diseases) 03/2021
1	Psoriatic Arthritis 03/2021
1	Interstitial Lung Diseases (Interstitial Lung Disease) 03/2021
1	Hidradenitis 03/2020
1	Hyperhidrosis 03/2020
1	Miliaria (Prickly Heat) 03/2020
1	Neuroblastoma 03/2020
1	Mycosis Fungoides 11/2019
1	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous) 11/2019
1	X-Linked Syndrome Enteropathy Polyendocrinopathy Immune Dysregulation 12/2018
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2018
1	Genetic Predisposition to Disease (Genetic Predisposition) 01/2018
1	Arthus Reaction 01/2017
1	Dermatitis 11/2016
1	Oral Lichen Planus 11/2016
1	Edema (Dropsy) 09/2015
1	Drug-Related Side Effects and Adverse Reactions 01/2013
1	Hypothermia 04/2012

Drug/Important Bio-Agent (IBA)

32	AutoantibodiesIBA 03/2022 - 09/2012
16	Collagen Type XVIIIBA 03/2022 - 04/2009
12	Immunoglobulin G (IgG)IBA 01/2022 - 04/2009
11	Collagen Type VIIIBA 01/2022 - 09/2012
7	AntibodiesIBA 01/2022 - 05/2015
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2013
6	AutoantigensIBA 12/2021 - 01/2016
6	EpitopesIBA 07/2020 - 05/2015
5	AntigensIBA 12/2021 - 04/2009
5	Matrix Metalloproteinases (MMPs)IBA 12/2019 - 01/2018
3	Pharmaceutical PreparationsIBA 03/2021 - 01/2013
2	CollagenIBA 01/2022 - 01/2019
2	CytokinesIBA 09/2021 - 04/2015
2	Cell Adhesion Molecule-1IBA 11/2019 - 12/2018
2	Interleukin-6 (Interleukin 6)IBA 01/2018 - 04/2015
2	Complement System Proteins (Complement)IBA 12/2017 - 06/2013
2	EnzymesIBA 11/2017 - 10/2017
2	Desmoglein 3IBA 10/2017 - 11/2016
1	SulfonesIBA 03/2022
1	diphenyl (biphenyl)IBA 03/2022
1	Immunoglobulins (Immunoglobulin)IBA 03/2022
1	Immunoglobulin M (IgM)IBA 03/2022
1	VaccinesIBA 01/2022
1	Therapeutic UsesIBA 01/2022
1	Adalimumab (Humira)FDA Link 01/2022
1	Peptide Hydrolases (Proteases)FDA Link 01/2022
1	Rituximab (Mabthera)FDA Link 12/2021
1	EpiregulinIBA 09/2021
1	InterleukinsIBA 09/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2021
1	Interleukin-17 (Interleukin 17)IBA 09/2021
1	EGF Family of ProteinsIBA 09/2021
1	Prednisolone (Predate)FDA LinkGeneric 04/2021
1	Methotrexate (Mexate)FDA LinkGeneric 03/2021
1	Biological ProductsIBA 03/2021
1	CatecholaminesIBA 03/2020
1	Rheumatoid FactorIBA 01/2019
1	Carrier Proteins (Binding Protein)IBA 01/2019
1	Dipeptidyl-Peptidase IV InhibitorsIBA 01/2018
1	Biomarkers (Surrogate Marker)IBA 01/2018
1	HLA-DQB1 antigen (HLA DQB1)IBA 01/2018
1	Immune Checkpoint InhibitorsIBA 12/2017
1	ImmunosorbentsIBA 11/2017
1	Intravenous Immunoglobulins (IVIG)FDA Link 01/2017
1	Protein Kinase CIBA 12/2016
1	DesmogleinsIBA 11/2016
1	Messenger RNA (mRNA)IBA 09/2015
1	von Willebrand FactorIBA 09/2015
1	Interleukin-1 (Interleukin 1)IBA 04/2015
1	CaspasesIBA 12/2014
1	Cysteine Proteases (Cysteine Protease)IBA 12/2014
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2014
1	SaltsIBA 09/2013
1	LipopolysaccharidesIBA 04/2012
1	Coloring Agents (Dyes)IBA 04/2012
1	Interleukin-18 (Interleukin 18)IBA 04/2012
1	NLR ProteinsIBA 04/2012

Therapy/Procedure

3	Therapeutics 12/2021 - 04/2015
1	Ostomy 01/2022
1	Biological Therapy 03/2021